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R 4-OH catechol estrogens that are not methylated by COMT can be oxidized to quinones that generate reactive oxygen species and form DNA adducts, a mechanism implicated in estrogen-dependent cancers

Christensen, K., Frederiksen, H

[Google Scholar] 306.Porter TM

Mitochondrial Dysfunction as a Force Multiplier Mitochondria act as both generators and sensors of oxidative stress, amplifying redox imbalance and accelerating cellular dysfunction across metabolically active tissues