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Activating Nrf2 thus offers a dual benefit: it strengthens anti-ferroptotic defenses while actively supporting therapies designed to raise native FXN levels

In cases where this process is disrupted, such as bacterial infection, neutrophil accumulation persists, leading to elevated levels of elastase and matrix metalloproteinases (MMPs) that degrade the extracellular matrix (ECM) and impair tissue repair [27]

Direct determination of faecal wet weight by lyophilisation was considered inappropriate because this underestimates relative faecal wet weight due to evaporation of water from the faecal pellets in the collection vessels of the metabolic cages