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The right panel shows the progression of liver diseases (MASLD, ALD, cirrhosis, HCC), marked by gut dysbiosis with reduced diversity and the enrichment of pathogenic taxa such as Enterobacteriaceae and Klebsiella

Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages

A proof-of-concept phase 2 study compared two doses (50 and 150 mg) of this first-in-class drug to placebo in PD patients on dopaminergic treatment with an OFF-time of at least 2 h [152]

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