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Some studies have shown an increased risk of depression and cognitive disorders in individuals with T2D taking metformin and vitamin B12 deficiency [61,62]

While the evidence is mixed for supplementation in people who aren't deficient, studies show modest benefits for fat utilisation during exercise particularly in those with lower baseline levels, including vegetarians and older adults

Many mediators are linking to intrinsic (e.g., organelle homeostasis, chronic inflammation, and epigenetic alterations) and extrinsic factors (e.g., UV exposure, drug toxicity, and lifestyle) that deteriorate cell physiology

GhGPX6, 810, 12 were grouped into clade I, GhGPX1, 3, 5 into clade II and the GPXs in sub-classification of clade II, including GhGPX1, PtGPX1, AtGPX1, 7 and OsGPX6, 8 were all predicted to have the subcellular localisation of the chloroplast or mitochondria (Table 4)