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569 Their chemical structure, dosage form, and administration route are the main determinants of their absorption, distribution, metabolism, and excretion, thereby affecting their efficacy and safety

Sturme MHJ, Nakayama J, Molenaar D, Murakami Y, Kunugi R, Fujii T, et al

No symptoms of chronic toxicity nor pathological organ changes were detected in rats fed 50 or 200 mg/daily of calcium pantothenate during 190 days nor in dogs (daily dose 50 mg/kg) and in monkeys (1 g daily for 45 kg body weight) fed for 6 months

For persistent or stubborn pigmentation, dark lips treatments such as topical creams, laser therapy, or vitamin supplementation may be necessary