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I rotate between Tylenol (mainly), Excedrin, and NSAIDs, with caution

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SAM is an allosteric activator of CBS [8] and an allosteric inhibitor of methylentetrahydrofolate reductase (MTHFR) [9]

Notably, H3K9la and RAD51K73la share the same upstream regulator GCN5, which represents a potential target [70]