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However, this same sensitivity to external stimuli such as sensory deprivation or early life stress can render them vulnerable to dysfunction (155)

The Buffalo group reported its use in 31 cases at their institution with no associated complications [38]

Locally produced IGF-1 also contributes to autocrine and paracrine signallingtissues produce their own IGF-1 in response to GH stimulation, creating local high concentrations even when systemic IGF-1 remains modest

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