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Description

Liquid Chromatography Tandem Mass Spectrometry in the Clinical Laboratory

Epub 20230822

When a persons immune system is exposed to bacteria or a virus, it learns how to combat the infection and creates a memory to be more effective at tackling it the next time we get sick

therefore, compared to in vivo conditions, higher levels of cystine in standard cell culture media drive more SLC7A11-mediated cystine uptake and glutamate export, resulting in more glutamine dependency and more cellular sensitivity to glutaminase inhibition (Muir et al., 2017)