Other reactions, such as exchanges of atoms of [H + N] (e.g., amination), [H + N O] (e.g., hydrolysis of amide), [2H + C] (e.g., methylation), [2H + O] (e.g., hydration) and [2H] (e.g., reduction), were also among the top-ranked unknown reactions (Fig
Gexia Zhuyu Decoction has been found to modify miRNA-24 and transient receptor potential melastatin 4 (TRPM4) expression, thereby enhancing NAFLD treatment efficacy in mice [155]
& Thurman, R
While classical presentations with malabsorption, chronic diarrhea, and failure to thrive still occur, predominantly in younger children, non-classical, oligosymptomatic, and asymptomatic forms now predominate ( In parallel with these changes, metabolic syndrome (MetS) has emerged as a major public health concern in children and adolescents, largely driven by the global rise in pediatric obesity ( Against this background, growing evidence suggests an emerging overlap between CD and obesity-related comorbidities ( This review aims to examine the risk of developing MetS in pediatric patients with CD by synthesizing current clinical and epidemiological evidence, exploring potential pathophysiological mechanisms, evaluating the impact of a GFD, and discussing how these insights can shift CD from a cardiometabolic risk to a preventive opportunity in the perspective of childrens health, emphasizing early nutritional and preventive strategies to support long-term cardiometabolic well-being
