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Bao Yuan decoction alleviates fatigue by restraining inflammation and oxidative stress via the AMPK/CRY2/PER1 signaling pathway

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A systematic review (PMID: 40756949) examined its emerging use in orthopaedic sports medicine, while a 2025 pilot study (PMID: 40131143) provided early human safety data

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Following this, the receptors were then embedded in a rectangular 126 x 126 1-palmitoyl-2-oleyl-sn-glycerol-3-phosphocholine (POPC) bilayer (previously built by using the VMD Membrane Builder plugin 1.1 at considering the coordinates retrieved from the OPM database to gain the correct orientation within the membrane, while removing the lipid molecules overlapping the receptor TMD bundle

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