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Although the favourable effect of tirzepatide on this endpoint appeared to be predominantly driven by a reduction in new onset macroalbuminuria [22], it is worth noting that the differences in changes in albuminuria during the time course of the study were mainly attributable to a progressive increase in the insulin glargine group whereas levels remained relatively stable in the tirzepatide-treated group

245,246 In a randomized controlled trial involving patients with essential hypertension, specific SLC22A12 single nucleotide polymorphisms (SNPs), such as rs11602903, were associated with higher body mass index (BMI), larger waist circumference, higher HDL cholesterol levels, and the presence of metabolic syndrome in individuals of European descent

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