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When comparing apheresis-derived T cell material of the two groups, the research group observed a significantly higher percentage of CD8 + T cells expressing PD-1 and LAG-3 in the dysfunctional response group than in the functional response group, suggesting that treatment failure and short-term recurrence were closely related to initial cell phenotype before infusion

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The generated Fe3+/Fe2+ ions, through the Fenton reaction, convert intracellular H2O2 into hydroxyl radicals (OH), which in turn induce ferroptosis, enhancing DOX-induced apoptosis