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Dihexa was administered to the APP/PS1 mice intraperitoneally from 6 to 9 months of age and 0.9% saline was administered to the wild type group once per day over a three month time period

doi: 10.3390/ijms23169297

In line with these findings, administration of proteasome inhibitors in rat models of -synuclein overexpression causes significant microgliosis and -synuclein aggregation [238, 239]