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Glossary EEDs Environmental Endocrine Disruptors AR Androgen Receptor ER Estrogen Receptor Er/ER Estrogen Receptor Alpha/Beta SRC-1 Steroid Receptor Coactivator-1 GPCR G-Protein-Coupled Receptor PKA Protein Kinase A cAMP Cyclic Adenosine Monophosphate Ca Calcium Ion HSD17B 17-Hydroxysteroid Dehydrogenase CYP19 Cytochrome P450 Aromatase CYP1A1/CYP3A4 Cytochrome P450 Family 1A1/3A4 GSH Glutathione GST Glutathione-S-Transferase ROS Reactive Oxygen Species Drp1 Dynamin-Related Protein 1 Mfn2 Mitofusin 2 PINK1 PTEN-Induced Kinase 1 ARE Androgen Response Element miRNA MicroRNA lncRNA Long Non-Coding RNA NEAT1 Nuclear Paraspeckle Assembly Transcript 1 DMR Differentially Methylated Region DNMT1/3A/3B DNA Methyltransferase 1/3A/3B TET1/2 Ten-Eleven Translocation Methylcytosine Dioxygenase 1/2 EZH2 Enhancer of Zeste Homolog 2 KDM6B Lysine Demethylase 6B piRNA Piwi-Interacting RNA LINE-1 Long Interspersed Nuclear Element-1 NMDR Non-Monotonic Dose-Response TEF Toxic Equivalence Factor TDI Tolerable Daily Intake ED50 Median Effective Dose BCF Bioconcentration Factor PCB Polychlorinated Biphenyl PAHs Polycyclic Aromatic Hydrocarbons PBDEs Polybrominated Diphenyl Ethers BPA Bisphenol A DEHP Di(2-ethylhexyl) Phthalate HBCD Hexabromocyclododecane PCDD/Fs Polychlorinated Dibenzo-p-dioxins and Furans AGD Anogenital Distance iPSCs Induced Pluripotent Stem Cells scRNA-seq Single-Cell RNA Sequencing ATAC-seq Assay for Transposase-Accessible Chromatin using Sequencing CRISPR Clustered Regularly Interspaced Short Palindromic Repeats ROI Return on Investment FSH Follicle-Stimulating Hormone LH Luteinizing Hormone MDA Malondialdehyde SOD Superoxide Dismutase NOAEL No Observed Adverse Effect Level WHO World Health Organization EFSA European Food Safety Authority EPA Environmental Protection Agency

Ebselen is therefore a potent bifunctional pharmacological chaperone for SOD1 that combines properties of the SOD1 chaperone hCCS and the recently licenced antioxidant drug, edaravone

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Higher doses of EPA (a specific omega-3) seem linked to better results