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Retrieved 2025-11-14

IM injections into the same muscle group create cumulative microtrauma that alters local blood flow and lymphatic drainage, which degrades absorption consistency by week 46 of a protocol

In practice, slower addition takes only a little longer and prevents the much larger cost of a failed vial

[5] In summary, pyridoxine may decrease the efficacy of certain medications (notably levodopa and some anticonvulsants), and various drugs can in turn precipitate vitamin B deficiency