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et al., NNMT regulates cellular metabolism through NAD and methyl donor balance, Nature Chemical Biology, 2013

The studies indicated that AHK's presence may have raised collagen type I production, with a threefold increase compared to the control group

And, the more serious side effects, such as blood clots or congestive heart failure, are likely to occur in individuals who are already treating a preexisting condition, have heart conditions, or in those who are genetically predisposed to these conditions