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doi: 10.1124/jpet.106.107482 110 KukJ

GHK-Cu is the most accessible entry point, with validated topical formats that do not require injection

sequence targeting such as genome perturbation or gene-editing CRISPR Clustered Regularly Interspaced Short Palindromic Repeats the CRISPR/Cas or the CRISPR-Cas system does not require the generation of customized proteins to target specific sequences but rather a single Cas enzyme can be programmed by a short RNA molecule to recognize a specific DNA target, in other words the Cas enzyme can be recruited to a specific DNA target using said short RNA molecule