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The inflammatory response significantly contributes to the progression of PD, and recent research suggests that nicotine may exert anti-inflammatory effects by inhibiting microglia and astrocyte activation and reducing the production of pro-inflammatory cytokines (Srinivasan et al., 2016)

NOVEMBER 2018 UPDATE: The latest word is that the revised ACVIM Consensus Statement on mitral valve disease in small dogs will not be published until late 2019, following the June 2019 ACVIM annual forum in Phoenix, Arizona