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This suggests that there might be different lipid metabolic pathways in the two subtypes of HF, and inhibiting myocardial energy deficiency, by restoring ATP-dependent LV relaxation and contraction, might cause beneficial effects in HFpEF [7]

Kozlowski MT, Crook CJ, Ku HT (2021) Towards organoid culture without matrigel

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Therefore, this metabolic microenvironment of solid tumors can be recapitulated, and throughout the study we used 0.5 mM glucose in media to recapitulate glucose deprivation and, on top of this, added 20 mM lactic acid for a mimicry of lactic acidosis