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Some research suggests that nicotine itself, independent of smoking, may improve cognition and potentially reduce the risk for dementia

The earliest depiction of an English man smoking tobacco. Image HathiTrust Digital Library Source 1a-c: A Description of the now discouered Riuer and Country of Virginia, with the liklyhood of ensuing ritches, by Englands ayd and industry, 1607

Acetylcholine is released by preganglionic sympathetic fibers of these nerves and nicotinic acts on these acetylcholine receptors, causing the release of epinephrine (and norepinephrine) into the bloodstream

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