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Specifically, alkylation of a C3-amino-quinoline derived precursor, such ascompound8, may be achieved via reductive amination with, for example, triethyl orthoformate in TFA followed by treatment with NaBH 4 to give the corresponding secondary C3-amine derivative (such as N-methyl-C3-amino-quinoline 9)

96 In a controlled trial that included 37 couples with male infertility, incubating sperm in a myo-inositol-enriched medium prior to artificial insemination (intrauterine) was shown to improve sperm motility and increase the chance of pregnancy