cysteine converted to glutathione peroxidase Frontiers Most relevant steps of glutathione

Hgt1p, a high affinity glutathione transporter from the yeast Saccharomyces cerevisiae

Consider these research findings: Biofilm formation: Bacterial biofilms can form in chronic nummular lesions, contributing to treatment resistance [3] Altered drug penetration: The thick, scaly (hyperkeratotic) nature of chronic lesions can reduce the absorption of topical medications [13] Neurogenic inflammation: The density of nerve fibers containing Substance P, a neuropeptide involved in inflammation and itching, is significantly increased in nummular eczema lesions [14] Most frustrating is the rebound phenomenon that can occur after discontinuing topical steroids, which can lead to a dependency cycle [15]

10.1038/nrneurol.2015.218 Nat

Immunosuppressive therapies, including corticosteroids and drugs such as rituximab or azathioprine, are widely used to reduce immune-mediated attacks on the CNS