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Age-associated microenvironmental changes highlight the role of PDGF-C in ER+ breast cancer metastatic relapse

YH, JD, and MM: software

In contrast, tumors with low phosphorylated ERK expression may exhibit resistance (Huang et al., 2023[55])

124 The activation of oncogenic pathways enhances the production of intracellular ROS, which, in turn, leads to the activation of oncogenes in a vicious circle that boosts cell proliferation and drives aggressiveness of cancer cells, thus affecting the outcome in cancer patients