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Therapeutic Use in Pediatric Populations Clinical trials in children with idiopathic growth hormone deficiency showed therapeutic efficacy: Daily subcutaneous sermorelin 30 mcg/kg at bedtime significantly increased height velocity in prepubertal children Sustained growth acceleration maintained through 12-36 months of treatment in published studies Catch-up growth achieved in approximately 74% of treated children in 6-month trials Greatest responses observed in children with delayed bone age and lower baseline growth rates However, sermorelin required higher doses than initially anticipated and demonstrated lower potency compared to recombinant growth hormone, leading to commercial discontinuation despite proven safety

Practice Parameters Committee of the American College of Gastroenterology

doi: 10.1016/j.niox.2014.09.051 31 SchaafMBGargADAgostinisP