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Description

The actions of cytosolic glutaredoxins (GRX) or cytosolic and mitochondrial thioredoxins (TRX1 and TRX2) restore the oxidized proteins back to their reduced state

In vitro CCK-8 assay of SH-SY5Y (neuronal) and BV2 (microglial) cells demonstrated low cytotoxicity up to 0.5 mM

doi: 10.3389/fphar.2020.569551

More recently, it has been demonstrated that NSC-34 cells expressing TDP-43 mutants also exhibit shortened neurites, increased OS, and decreased HO1 level, and these effects can be reversed by the UPS inhibitor MG132, but not by the Nrf2 activator sulforaphane [255, 256], probably because MG132 induction of HO1 is Nrf2 independent