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Statistical analyses were performed using GraphPad Prism (v.10.0.3), R (v.4.3.0) and SCiLS

Maltepe E, Saugstad OD

Mitochondria, being the primary organelles producing ROS within cells, generate ROS that can attack various mitochondrial components, leading to increased mtDNA mutations and oxidative damage to associated respiratory chain enzymes ( mtDNA mutations and aging mtDNA mutations also affect individual and cellular aging, with the accumulation of mtDNA mutations increasing with age ( Genomic instability and aging Genomic instability in the nucleus can influence mitochondrial physiology during aging through so-called anterograde stimulation ( The role of mitochondria in cell death Cell death is a crucial regulatory mechanism for maintaining organismal homeostasis

[DOI] [PubMed] 110.Gorard DA, Davies SE, Clark ML