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Single-cell metabolic profiling studies have revealed remarkable diversity in metabolic states even among cancer cells with identical genotypes, suggesting that stochastic or microenvironmental factors create metabolic subpopulations

The Lilly company would be delighted to work with Toronto, Clowes wrote, and hinted, perhaps intentionally, perhaps not, that Toronto could be bypassed: "I have thus far refrained from starting work in our laboratories on the field of this question as I was anxious to avoid in any way intruding on the field of yourself and your associates until you had published your results