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Other components including IgA, enzymes, proteins such as lactoferrin and those with antimicrobial properties including bile acids and AMPs, are also present in these mucosal layers and function collectively to restrict the interaction of luminal contents with the epithelial layer (Singh et al

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Or, and this is a bigger question, might carnivores already sidestep many of the underlying metabolic issues that make higher-dose supplementation so impactful in the first place