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RNA-seq was performed to identify the differential gene expression and pathways

*Correspondence: Xiaohong Xiang [email protected] This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Such modifications can form mono-ubiquitination, poly-ubiquitination, and poly-ubiquitin chains

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