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Increased expression of Bax increases permeability of the mitochondrial membrane, leading to the release of apoptosis-inducing factors from the mitochondria into the cytoplasm, activating cysteoaspartic enzymes and leading to apoptosis

Front Immunol (2020) 11:924

Interestingly, the function of the affinity-isolated proteins reveals that both HPX and Tf are linked with the protective immune responses and iron transport

Unlike other members of the nuclear receptor family, the ligand binding cavity of ERs accommodates a wide range of structurally different compounds, including metabolites of estrogen and even environmental contaminants referred to as endocrine disruptors (Heldring et al., 2007)