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[DOI] [PubMed] [Google Scholar] 97.Smith E.M., Pang H., Cirrincione C., Fleishman S., Paskett E.D., Ahles T., Bressler L.R., Fadul C.E., Knox C., Le-Lindqwister N., Gilman P.B., Shapiro C.L

S.KomatsuM.et al (2013)

Pharmacologic and genetic suppression of GPX4 induces ferroptosis, DNA damage, and decreased cell viability in vitro via a novel mechanism of mTOR signaling pathway inhibition

In mice, the gene analogous to the human 15-LOX encodes a lipoxygenase that converts arachidonyl chains to both 12-HPETE and 15-HPETE and is thus a 12/15-LOX