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Encapsulation and delivery strategies Phytochemicals low solubility in aqueous medium restrict their applications in food and pharmaceutical products, thus, encapsulation is a tool to enhance their stability, bioavailability and bio-efficacy by protecting them against adverse environmental conditions, improving retention time and controlled release at target sites (82, 83)

Extended-interval dosing is associated with equivalent efficacy and reduced nephrotoxicity, with a non-significant trend toward lower ototoxicity in pooled analyses

Oral administration of 2 g of vitamin C in healthy populations helped to reduce aggregation platelet and arterial stiffness, however, the exact mechanism has not been fully explored (Wilkinson et al

Importantly, the dependency on riboflavin and subsequently impaired oxidative phosphorylation upon perturbation of riboflavin metabolism can be exploited by sensitizing AMLs to the BCL-2 inhibitor venetoclax