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In contrast, depletion of microglia reduced alcohol consumption in mice, decreased anxiety-like behavior, and reduced GABA and glutamate receptor-mediated synaptic transmission in the central nucleus of the amygdala (168)

Mechanistically, we observed that WT XKR8, but not the 2DA mutant, underwent cleavage upon PMA stimulation in dHL-60 cells, highlighting the importance of caspase-3-dependent XKR8 activation in NET formation (Fig

Cullen KR, Schreiner MW, Klimes-Dougan B, Eberly LE, LaRiviere LL, Lim KO, et al