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Across STEP 1, STEP 3 and STEP 4, treatment with semaglutide 2.4 mg was associated with a significant 30% HOMA-IR reduction 73

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No obstante, las acciones del IGF-1 se atenan en el contexto de la enfermedad renal, que puede deberse a la presencia de factores inhibidores, como las protenas de unin al IGF, y a la incapacidad de activar la sealizacin intracelular a pesar de una expresin normal del receptor de IGF-1 en la superficie celular