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Defective bacterial phagocytosis is associated with dysfunctional mitochondria in copd macrophages

In studies of neutralizing mAbs (Supplementary Table 1), viral titres and lung pathology after nasal challenge were reduced in rhesus macaques that were administered a mAb directed against a proteolytic cleavage site in the SARS-CoV S protein that is required for host-cell entry 134

These changes are almost always temporary and reversible

To enhance the accumulation of O 2 and photosensitizers within mitochondria precisely, hexyl 5-aminolevulinate hydrochloride (HAL) and 3-bromopyruvic acid (3BP) were simultaneously encapsulated into microparticles of X-ray irradiated tumor cells (X-MP) to prepareHAL/3BP@X-MP for potent PDT (Figure 5A) (Zuo et al., 2021)