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Protein thiols are also major targets of reactive oxygen species in vivo and oxidative conversion of thiols into disulfides and their subsequent reduction ( e.g., see Figs

The nigrostriatal pathway is particularly vulnerable to oxidative stress, neuroinflammation, and genetic mutations (e.g., parkin) due to its high synaptic density, extensive unmyelinated axonal networks, and elevated metabolic demands (Hegarty et al., 2013