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Regarding the prenatal period, a significant RCT involving pregnant women positive for anti-thyroid peroxidase antibody (TPOAb), demonstrated that selenium supplementation led to a notable reduction in TPOAb levels during and after pregnancy [20,33]

However, this is unlikely to uncover higher levels of toxicity than predicted here, as infants have lower hepatic enzymatic activity than adults 19,21,22,30 , leading to lower production of haemolytic metabolites compared to adults or older children

Trace elements in type 2 diabetes mellitus and their association with glycemic control