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[3] Biological activity: The glutathione redox cycle Glutathione exists in two interconvertible forms, reduced glutathione (GSH) and oxidized glutathione (GSSG)

Its highest concentrations are found in the liver, the bodys central organ for detoxification, where it plays a vital part in neutralizing harmful free radicals, supporting phase I and phase II liver detoxification pathways, and helping to eliminate heavy metals and environmental toxins

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2 Mechanisms of redox regulation in the CNS 2.1 GSH as an antioxidant in the brain The brain, being one of the most metabolically active organs in the body, requires a large share of oxygen relative to its mass