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40 , 41 Given that even on the same dose of substrate precursor in loading tests there is a big variation in the amount of TMAO and TMA excretion, it is possible that the nature of the gut microflora may play a significant role in the generation of symptoms in some individuals

Reduced expression of TRH in the hypothalamus appears to play a key role in the prolonged phase of critical illness, although the processes that trigger this upstream disturbance are somewhat unclear

These results highlight the significance of controlling LC intake because an excess of this dietary component raises TMAO levels, which in turn raises cardiovascular risk

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