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While one pilot study showed two people tolerating 20mg intravenously, that does not guarantee that long-term daily injections are safe

Gafforov Y, Raeta M, Rapior S, Yarasheva M, Wang X, Zhou L, Wan-Mohtar WAAQI, Zafar M, Lim YW, Wang M, Bekhzod A, Bussmann RW, Zengin G, Chen J (2023) Macrofungi as medicinal resources in Uzbekistan: biodiversity, ethnomycology, and ethnomedicinal practices

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For example, changing Asp222 in AAT to Ala leads to a 10 5 -fold decrease in activity.[69] The difference between this result from mutagenesis and that with deazaPLP is presumably due to the fact that the D222A simply leads to deprotonation of the pyridine nitrogen, whereas deazaPLP fully exchanges the nitrogen for the less electronegative carbon atom