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The authors of one of these papers suggested that isotype switching could allow for HIV-infected individuals to respond to the escape of HIV from neutralization in a phenomenon they termed switch redemption 98

Neuron 75 904915

Primary research: Type 2 diabetes, obesity, metabolic disease Mechanism: Dual activation of GIP and GLP-1 receptors for enhanced metabolic effects Regulatory status: FDA-approved (Mounjaro 2022, Zepbound 2023) Key data: Up to 22.5% weight loss in SURMOUNT trials

These trials will involve patients with mutant p53 breast and colorectal cancer. After all these years, I still find it fascinating how cells change during our lifetime and contribute to aging and cancer. Why focus specifically on those types of cancer