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Collectively, lipid peroxidation is initiated by two classic pathways, including the enzymatic pathway and non-enzymatic pathway (Figure 1)

With high-dose methotrexate-based therapy, 2-year survival rates reach 4280.8%

Sonawane A, Hastekar A, Kakad A, Shaikh MR, Sharma R

Nevertheless, some experts have recommended that long-term treatment with thiols should be used in patients with exacerbation phenotype without chronic bronchitis, particularly in those with early stages of COPD with less severe airway obstruction, bronchiectasis with COPD overlap phenotype, and bronchitic phenotype with or without history of exacerbation [105]