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Abbreviations 2AP: 2-antiplasmin AGEs: advanced glycation end products CCL2: CC-chemokine ligand 2 CLTI: critical limb threatening ischemia CRP: C-reactive protein DAPT: dual antiplatelet therapy DM: diabetes mellitus DNase: deoxyribonuclease DOAC: direct-acting oral anticoagulants FXIII: factor XIII IKK: IB kinase IL-6: interleukin-6 JNK: JUN N-terminal kinase NETs: neutrophil extracellular traps NNT: number needed to treat NO: nitric oxide PAD: peripheral artery disease PAI: plasminogen activator inhibitor PKC: protein kinase C ROS: reactive oxygen species TF: tissue factor TFPI: tissue factor pathway inhibitor TNF-: tumor necrosis factor- tPA: tissue plasminogen activator uPA: urokinase-type plasminogen activator vWF: von Willebrand Factor References Ouriel K

In this prospective observational study, we examined the sequence in which symptoms of dependence present, and we assessed reciprocal relationships between smoking frequency and dependence over time

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