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Hb and heme levels are positively correlated with the Pfirrmann classification of disc degeneration Clinically, disc degeneration is graded according to the alteration in T2WI signal in the parasagittal MRI images of dysfunctional segments combined with Pfirrmann classification

One example I like to use that I think really illustrates where testing would wind up being really important is, lets say, imagine you have a woman who has the genetics for hemochromatosis and doesnt know it and because of the amount of menstrual fluid that she loses is lifelong predisposed to anemia

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As has been previously discussed, NO is felt to possess inherent anti-fibrotic properties