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Based on the genome sequence and protein expression levels of human epidermal growth factor 2 (HER2), progesterone receptor (PR) and estrogen receptor (ER), breast cancer can be divided into luminal, HER2-enriched and triple-negative types (2)

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allelic model: p = 0.002) ( PTPN22 rs2476601 variant (OR = 1.81, as reflected in pooled meta-analyses) in European populations augments autoreactive T-cell activation through impaired T-cell receptor signaling via lymphocyte tyrosine phosphatase ( CTLA4 mitigates autoimmune risk (OR = 0.88) by suppressing T-cell co-stimulation, particularly in ACPA-positive subtypes (Stahl et al., 2010)

The ability of these compounds to influence metabolic pathways underscores the importance of dosage and timing in achieving beneficial effects while minimizing potential toxicity