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10.1177/0960327107083452 Hum Exp Toxicol

Multiple studies have shown that miRNAs target genes that encode histone-modifying enzymes, such as HDAC, DNMT, and EZH, thus highlighting the relationship among ncRNAs, DNA methylation, and histone modification [40, 41]

Similarly, resistance to oxidative attack increased after overexpression of GPX5 in CHO-K1 cells, and GPX5 overexpressing cells reduced lipid peroxidation levels and downstream DNA damage marker 8-OXODG levels compared to control cells (Taylor et al., 2013)

Safety profile : Periodic breaks allow the body to return to baseline and minimize any potential unknown long-term effects