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Researchers studying overlapping pathways order the blend

NICE Clinical Knowledge Summaries recommend B12 injections for: Pernicious anaemia an autoimmune condition affecting intrinsic factor production Malabsorption syndromes including coeliac disease and inflammatory bowel disease Post-surgical states particularly following gastrectomy or ileal resection Strict vegan diets when oral supplementation proves inadequate, though oral cyanocobalamin is usually sufficient for dietary deficiency Clinical trials demonstrate that B12 injections rapidly improve haematological parameters and neurological symptoms when deficiency is confirmed through blood tests

The thing I think the medical and policy community is going to have to come to terms with is that the standard model (drug gets developed, drug gets approved, drug gets prescribed, drug enters consumer awareness) has been inverted for an entire emerging class of compounds

Despite these advances, there remains a critical need for robust post-marketing surveillance to capture real-world toxicity data beyond the controlled settings of clinical trials