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Furthermore, GDF15 (growth differentiation factor 15), a member of the TGFB superfamily produced by stressed cells, plays a role in reducing food intake by binding to its receptor GFRAL (GDNF family receptor alpha like) in the area postrema [208]

However, separating and purifying this specific phospholipid is challenging as the tedious and elaborate process involves high-performance liquid chromatography and mass spectrometry with high-purity standards for comparison

5 Autophagy in CP-induced AKI 5.1 Introduction of autophagy pathway 5.1.1 An overview of autophagy and its main types In the late 1960s, Christian de Duve, the Nobel Laureate, first introduced the concept of autophagy

The peptides mechanism of action, however, remains only partially understood, and its receptor system has yet to be definitively identified