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The triple mutant strain was found to be hypervirulent in an invasive murine model and showed increased tolerance to H2O2 stress relative to that of the wild type.279 These authors suggested that part of the increased virulence of the triple mutant strain might be due to the Ppo-generated prostaglandins, which could enhance host defense mechanisms, perhaps through initiation of inflammation responses involved in recruiting phagocytic cells

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(2) 20% of EOM contain multi-terminal fibres, which have sparse junctional folds, lower AChR density and do not have a safety factor