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There were eight pro-oxidant factors as follows: saturated fatty acid (SFA), omega-6 poly-unsaturated fatty acid (PUFA), total iron intake, total copper intake, and statuses pertaining to smoking, drinking, obesity, and abdominal obesity

Considering the close phylogenetic similarity between ALK7 and the TGFb pathway receptors ALK4 and ALK5 [30,31,32], we hypothesized that ALK4 and ALK5 might be potential off-targets of the ALK7 esiRNA